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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF2C2 All Species: 29.7
Human Site: S185 Identified Species: 54.44
UniProt: Q9UKV8 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UKV8 NP_001158095.1 859 97208 S185 G R S F F T A S E G C S N P L
Chimpanzee Pan troglodytes XP_001142838 813 92351 W165 Q S V R P S L W K M M L N I D
Rhesus Macaque Macaca mulatta XP_001100725 1053 117937 S377 G R S F F T A S E G C S N P L
Dog Lupus familis XP_532338 899 101246 S225 G R S F F T A S E G C S N P L
Cat Felis silvestris
Mouse Mus musculus Q8CJG0 860 97305 S186 G R S F F T A S E G C S N P L
Rat Rattus norvegicus Q9QZ81 860 97300 S186 G R S F F T A S E G C S N P L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513588 873 98974 S199 G R S F F T A S E G C S N P L
Chicken Gallus gallus Q5ZLG4 860 97253 P186 G R S F F S A P E G Y D H P L
Frog Xenopus laevis Q6DCX2 862 97626 S188 G R S F F T A S E G C A N P L
Zebra Danio Brachydanio rerio A3KPK0 860 97313 P186 G R S F F S S P E G Y D H P L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VUQ5 1214 136831 S559 G R S F F K M S D P N N R H E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34681 1040 115397 K255 S A N F Y T W K S S C Y R I P
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O04379 1048 116172 D344 G R S F Y S P D I G K K Q S L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.6 80.2 95.3 N.A. 98.9 99 N.A. 97.1 79.7 96.1 79.4 N.A. 22.4 N.A. 33.4 N.A.
Protein Similarity: 100 94.6 81 95.3 N.A. 99 99.3 N.A. 97.5 89.3 98.2 89.4 N.A. 36.4 N.A. 51.5 N.A.
P-Site Identity: 100 6.6 100 100 N.A. 100 100 N.A. 100 66.6 93.3 60 N.A. 40 N.A. 20 N.A.
P-Site Similarity: 100 20 100 100 N.A. 100 100 N.A. 100 80 100 80 N.A. 53.3 N.A. 33.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 37.5 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 53.4 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 40 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 53.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 0 0 62 0 0 0 0 8 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 62 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 8 8 0 0 16 0 0 8 % D
% Glu: 0 0 0 0 0 0 0 0 70 0 0 0 0 0 8 % E
% Phe: 0 0 0 93 77 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 85 0 0 0 0 0 0 0 0 77 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 16 8 0 % H
% Ile: 0 0 0 0 0 0 0 0 8 0 0 0 0 16 0 % I
% Lys: 0 0 0 0 0 8 0 8 8 0 8 8 0 0 0 % K
% Leu: 0 0 0 0 0 0 8 0 0 0 0 8 0 0 77 % L
% Met: 0 0 0 0 0 0 8 0 0 8 8 0 0 0 0 % M
% Asn: 0 0 8 0 0 0 0 0 0 0 8 8 62 0 0 % N
% Pro: 0 0 0 0 8 0 8 16 0 8 0 0 0 70 8 % P
% Gln: 8 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % Q
% Arg: 0 85 0 8 0 0 0 0 0 0 0 0 16 0 0 % R
% Ser: 8 8 85 0 0 31 8 62 8 8 0 47 0 8 0 % S
% Thr: 0 0 0 0 0 62 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 8 8 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 16 0 0 0 0 0 16 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _